Revista da Associação Médica Brasileira (English Edition) Revista da Associação Médica Brasileira (English Edition)
Rev Assoc Med Bras. 2013;59:622-8 - Vol. 59 Num.06

Homocysteine: cardiovascular risk factor in children and adolescents?

Adriana Amorim De Farias Leal a, Ástrid Camêlo Palmeira a, Gabriella Menezes Almeida De Castro b, Mônica Oliveira Da Silva Simões b, Alessandra Teixeira Ramos b, Carla Campos Muniz Medeiros b

a Post-graduation Program in Public Health, Universidade Estadual da Paraíba, Campina Grande, PB, Brazil
b Department of Pharmacy, Universidade Estadual da Paraíba, Campina Grande, PB, Brazil


Homocysteine. Cardiovascular diseases. Child. Adolescent


The aim of this study was to identify publications in literature that investigated Homocysteine (He) as a risk factor for CVD among children and adolescents. An active search for information in LILACS, IBECS, Science Direct, Medline and Cochrane Library databases was conducted using the following combination of keywords "homocysteine", "cardiovascular diseases", "child" and "adolescent". Fifteen articles were analyzed showing direct relationship with increasing age (8 studies) and male gender (10 studies), and an inverse relationship with serum vitamins B6, B12 and folate levels. Thus, the results suggest that more research must be carried through in order to determine in a more coherent way the causes of the hiperhomocisteinemia in the pediatric population, guiding for an adequate diet, rich in nutrients necessary to favor the metabolism of the He.

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